International Journal of Pathology Research

Vol. 3, Issue 1, Part A (2021)

Autipsy findings of sickle cell disorders in cases of sudden death


Rathod Kalpana B, Pohekar Raina, Nakate Leena

Sudden and unexpected death due to sickle cell crises is the commonest presentation in Sickle cell syndromes. In cases of deaths with no apparent cause and physical over activity medical officer must keep in mind the possibility of death due to vasoocclusive crisis in sickle cell disease while doing autopsy. To improve morbidity and mortality in sickle disease more precise analysis of causes of death is needed. This study carried out in the department of pathology, at tertiary care hospital overs the period from January 2018 to December 2019. The study was retrospective. The cases having history of sudden death were brought dead to the casualty were included in the present study. After post mortem examination, the specimens preserved and sent for histopathological examination. We found 17 cases of sickle cell anaemia autopsy cases. Out of 17 cases 13 were males and 4 were females. The youngest person was 13-year female and oldest was 48 years male. In clinical history 3 cases had complains of chest pain (17.64%), 7 others had complained of breathlessness (41.17%), 3 had history of unconsciousness (17.64%) and 2 had history of fever (11.76%) 1 case had a history of fall and injury (5.88%) 1 had pain in abdomen & vomiting (5.88%) 1 brought dead (5.88%). All organs microscopic examination was carried out. Wide spread congested blood vessels along with clogged of sickled RBC seen in all organ like lungs, liver, spleen, kidneys, heart and brain. The purpose of the study was to analyse and minimize future unexpected death due to complication and crisis of sickle cell disease.

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How to cite this article:
Rathod Kalpana B, Pohekar Raina, Nakate Leena. Autipsy findings of sickle cell disorders in cases of sudden death. Int. J. Pathol. Res. 2021;3(1):01-04.